Octisalate
Ethylhexyl Salicylate · 2-Ethylhexyl Salicylate
What it is
A UVB-absorbing organic UV filter (CAS 118-60-5) and avobenzone stabilizer used at up to 5% in US sunscreens.
In this product: UVB filter and avobenzone stabilizer.
Dose & route, what actually matters
Dermal absorption confirmed systemic (4.6–5.8 ng/mL plasma in JAMA RCT). Levels above the 0.5 ng/mL FDA threshold, additional safety data requested, but no specific harm finding identified.
EUROPEAN UNION
Permitted UV filter in EU Cosmetics Regulation. No SCCS endocrine-based restriction confirmed.
UNITED STATES
Permitted at up to 5% under FDA OTC Sunscreen monograph.
The evidence
2020 FDA-sponsored JAMA RCT: octisalate plasma concentrations 4.6–5.8 ng/mL on day 1 after single application. No specific harm finding identified in available evidence.
human · 2020 · source
California Prop 65: Not listed.
Where it hides
Editorial analysis of publicly available regulatory and peer-reviewed sources. Not medical advice. We name our evidence and link it, including when an ingredient is fine.